Scaffolds forlocalized drug delivery.
KINETIX develops 3D-printed scaffolds that hold a drug at the treatment site and release it over time. Computationally designed, with glioblastoma as our first research focus.
Investigational technology · Not approved for clinical use
The drug can’t workif it can’t reach the target.
Getting enough drug to the treatment site is a central delivery challenge. Biological barriers and distribution through the body can limit how much reaches the target.
Drug delivery explained · NIHWe place the drugat the treatment site.
We’re developing a scaffold that acts as a local drug depot. Placed at the treatment site, it holds a drug-loaded material within its pores and is designed to release the payload into the surrounding tissue.
Designed forcontrolled release.
Our scaffolds are designed to control how a drug is released over time. Architecture, material and formulation work together to tune the release profile at the treatment site.
Many drugs.Two ways to load.
Two complementary loading routes are designed to accommodate a wide range of drugs: incorporation into the polymer or delivery through a drug-loaded hydrogel. The route and formulation can be tailored to the payload.
The drug releasesinto nearby tissue.
The drug moves out of the scaffold and into surrounding tissue over time. We study how geometry, material and loading affect that release, then compare the model with experimental measurements.
Cyan particles represent the drug leaving the scaffold.
Refill the depotthrough one port.
A surface port connects to channels within the scaffold. Our reload concept routes a fresh dose through those channels and into the pore network, to replenish the local depot.
A fresh dose enters the surface port.
Illustrative mechanism · Under developmentStarting withglioblastoma.
Our first research focus is a scaffold placed in the surgical cavity after tumor removal. We’re investigating local delivery there while developing design tools that could support other tissues and therapies.
Brain anatomy · GBM research focus
Anatomy: Z-Anatomy / BodyParts3D · CC BY-SA 4.0
Develop the nextdrug-delivery system.
We’re looking for collaborators in drug formulation, biomaterials and preclinical research to help develop and test localized delivery systems.
contact@kinetix-dds.com